Individualized therapy in neuroblastoma
نویسندگان
چکیده
منابع مشابه
Individualized 131I-mIBG therapy in the management of refractory and relapsed neuroblastoma
OBJECTIVE Iodine-131-labelled meta-iodobenzylguanidine (I-mIBG) therapy is an established treatment modality for relapsed/refractory neuroblastoma, most frequently administered according to fixed or weight-based criteria. We evaluate response and toxicity following a dosimetry-based, individualized approach. MATERIALS AND METHODS A review of 44 treatments in 25 patients treated with I-mIBG th...
متن کاملWhole-body dosimetry for individualized treatment planning of 131I-MIBG radionuclide therapy for neuroblastoma.
UNLABELLED The aims of this study were to examine the relationship between whole-body absorbed dose and hematologic toxicity and to assess the most accurate method of delivering a prescribed whole-body absorbed dose in (131)I-metaiodobenzylguanidine ((131)I-MIBG) therapy for neuroblastoma. METHODS A total of 20 children (1-12 y), 5 adolescents (13-17 y), and 1 adult (20 y) with stage 3 or 4 n...
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UNLABELLED Clot formation in the circulation is a physiological mechanism preventing bleeding at sites of loss of vascular integrity. Clot formation may also occur intravascularly under pathological conditions, e.g. leading to myocardial infarction, stroke, and critical limb ischaemia. Clot formation involves activation of the coagulation cascade and of platelets eventually leading to an occlus...
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Pharmacogenetics deals with inherited differences in the response to drugs. The best-recognized examples are genetic polymorphisms of drug-metabolizing enzymes, which affect about 30% of all drugs. Loss of function of thiopurine S-methyltransferase (TPMT) results in severe and life-threatening hematopoietic toxicity if patients receive standard doses of mercaptopurine and azathioprine. Gene dup...
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T he phrase “divide and conquer” is thought to be derived from the Latin divide et impera, divide and rule. This refers to the maxim in politics or war to break up large, complex opponents into smaller, more manageable (and defeatable) entities. This technique might apply as well to the treatment of acute myeloid leukemia (AML). Genomic and molecular characterization has uncovered the widesprea...
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ژورنال
عنوان ژورنال: Russian Journal of Children Hematology and Oncology
سال: 2016
ISSN: 2413-5496,2311-1267
DOI: 10.17650/2311-1267-2016-3-4-36-47